We are delighted that we recently signed a contract to expand our space at Cambridge Park Drive (CPD Cambridge, MA) significantly. The expansion of the CPD facility is focused primarily on lab space and will bring together talent and expertise, especially to focus on cutting edge technologies. The lease for Rockville Vaccines site, where this role is currently being recruited, will expire by Q2 2026 and we have decided not to renew the lease. Consequently, this lab-based role may be relocated to Boston, Massachusetts in 2025.

As Associate Scientist within the Molecular Analytics platform, you will be in charge of implementing, designing and developing methods for the detection and quantification of nucleic acids based on up-to date nucleic acid technologies (NAT) and, in particular, methods aiming at characterizing plasmids (topology, conformation, sequence, quantity, etc.), mRNA Drug Substances (content, integrity, identity) and mRNA-LNP Drug products (monovalent and multivalent), used for production of mRNA vaccines. The use of direct nucleic acid quantification methods (e.g. CRISPR-based assays, digital counting through optical barcodes, branched DNA assays, etc.) will part of the activities of the hired Scientist.

You will join the Analytical Development Department, where the Molecular Analytics Platform is in charge of developing modern, state-of-the-art molecular methods to analyze (i.e. detect, identify, quantify and characterize) nucleic acids at all stages of vaccines development. You will be in charge of the design and development of NAT-based analytical methods to support product and process development, to develop and transfer release methods for GMP testing for Phase 1, Phase 2 and Phase 3, according to Quality by Design principles and in partnership with Technical Research and Development functions,

Quality and Regulatory. Work on the bench in the labs (> 70%) Interact with Belgium- and US-based team members Contribute to the development, qualification, validation and transfer of innovative genetic characterization assays/technologies based on state-of-the-art NAT Ensure the development of analytical methods for purity, identity and sterility Execute analytical methods for the genetic characterization of genetically engineered microorganisms, including recombinant plasmids Interact and act in a complex matrix with several stakeholders from different departments (Research, Development, QC, RA, QA) Interact with other GSK Vaccines R&D Centers (in US and IT) and external CMOs Ensure implementation of QbD (Quality by design) in the development of assays Agile principles driven

Develop detailed experimentation protocols and executes the planning/organization of the experiments in his/her scope of activities Analysis and interpretation of the data, including reporting and presentation Contribute to the various activities of the group

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• Bachelor's degree (biotechnology, molecular biology, biochemistry, molecular, bacteriology, molecular, microbiology).
• One or more years of experience in a lab environment focusing on analytics of biomolecules
• One or more years of experience in molecular biology (diversity of techniques and technologies as well as diversity of subjects.
• One or more years of experience in the following techniques: Nucleic acid extraction PCR, QPCR and ddPCR
• One or more years of experience in nucleic acid quantification methods (e.g. CRISPR-based assays, digital counting through optical barcodes, branched DNA assays, etc.
• One or more years of experience in molecular biology

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• MS Degree
• Experience in Bacteriology, Microbiology techniques, including plasmid biology, or Sanger and high throughput sequencing technologies.
• Design of primers and probes using recognized software's, design of LNA-containing primers and probes, design probes for multiplex assays, design of taqman probes,
• Experience with Molecular Biology techniques (including Southern blot, restrictions, reverse transcription, in vitro transcription, electrophoresis, etc.)
• Ability to conduct literature and online research, continuous search of new methods Identification of critical method parameters and plan to evaluate them
• Good writing skills Good Communicator Attention for details, eager to learn and driven by curiosity
• Variety of experience in different techniques such as: Nucleic acid extraction PCR, QPCR and ddPCR
• Direct nucleic acid quantification methods (e.g. CRISPR-based assays, digital counting through optical barcodes, branched DNA assays, etc.)

Why GSK?

#LI-GSK

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

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At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve.

GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons.

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