About Generate Biomedicines

Generate Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. Generate has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate was founded in 2018 by Flagship Pioneering and has received over $420 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Cambridge, Somerville, and Andover with approximately 250+ employees.

The Role:

Generate Biomedicines is seeking an experienced, creative, and motivated Scientist I/II to join our rapidly growing Platform Innovation team. This highly synergistic team works at the intersection of synthetic biology, microfluidics, microfabrication, micro-automation, organ-on-a-chip, and Machine Learning to establish truly novel biological and biochemical workflows that help enable high-throughput data generation throughout the company. The ideal candidate has a proven track record of developing platforms for advanced 3D cell culture systems including bioreactor systems and sensors that plays a central role in organ-on-a-chip devices. For this position, a strong background and hands-on experience building fluidic micropumps with controlled pressure and flow, integrated leak-free microfluidic system with air-bubble trapping system, sensors and actuators, and high-quality data acquisition and analysis are required. Additionally, experience with tissue culture, organoid models, immune functional assays, immunohistochemical staining are preferable, as the successful candidate will play an important role in integrating candidate bioreactor systems into bioprinted tissue constructs. On top of this, she/he will be responsible for onboarding new technologies, supporting cross-team high-throughput workflows including the development of novel translational models for immunogenicity risk assessment and toxicity assays. This is an opportunity to be part of a hugely diverse and interdisciplinary team that performs highly innovative technology development, in the premier scientific environment of a well-funded biotech startup.

Responsibilities include, but are not limited to:

• Design, assemble, and evaluate device platforms including bioreactors, flow sensors, microfluidic pumps for organ-on-a-chip and microfabricated systems. Oversee workflows, and, if necessary, perform effective design modifications.
• Assure candidate systems capabilities by performing quantitative validation assessments, be responsible for monitoring and modifications of the system
• Develop, qualify, and validate advanced in vitro cell culture models incorporating microphysiological systems, organoids, organ-on-a-chip approaches for drug screening and toxicity assessments
• Perform cell-based bioanalytical assays with standard readout techniques in combination with bioimaging technologies
• Independently design protocols, execute experiments, generate relevant data, apply advanced data analysis, and deliver findings with the highest possible scientific standard
• Participate in writing reports, electronic lab notebooks, publications, and patents

Qualifications:

• PhD in Biomedical Engineering, Bioengineering, Mechanical Engineering, or a related discipline or MSc with at least 8 years of relevant experience
• Solid knowledge of mechanical theories, principles, practices, proven hands-on experience on advanced tissue culture systems including lab-on-a-chip, 3D organoids, and microfluidic devices
• Strong knowledge of CAD/CAM, MATLAB, SolidWorks and PDM, data analytics tools
• Relevant theoretical and practical knowledge within the fields of cell biology, tissue engineering, microfabrication, microfluidics is highly desirable
• Outstanding laboratory technique: primary cell culture, cell-based bioanalytical assays including in vitro/ex vivo cytotoxicity assays, FACS, immunostaining and IHC, confocal microscopy
• Excellent communication and presentation skills to properly deliver the results and collaborate with diverse team members
• Self-motivated and scientifically driven with a desire to learn from and teach others, ability to work as a team in a multidisciplinary, dynamic, and result-oriented environment

Generate Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

COVID Safety:

Generate Biomedicines enforces a mandatory vaccination policy for COVID-19. All employees must be fully vaccinated and have received a booster. The purpose of this policy is to safeguard the health of our employees, their families, and the community at large from infectious disease that may be reduced by vaccinations. The company will make exceptions to this policy if required by applicable law and will consider requests for an exemption from this policy due to a medical reason, or because of a sincerely held religious belief, or any other exemptions that may be recognized by applicable.