We are currently seeking talented and motivated individuals to join the group of Cell Biology and Immunology in the R&D Department located in North Cambridge, Massachusetts. The successful candidate should possess extensive knowledge and hands-on experience in oncology, cell biology, and immunology, in particular, CAR-NK/CAR-T cell biology. The candidate will be able to contribute to the effort for developing a cell therapy platform, building and optimizing cell-based immunoassays to characterize and assess CAR-NK/CAR-T cell functions. Experience with CAR-NK/CAR-T cells is preferred. As major contributors to pipeline development, the candidates need to demonstrate the ability of planning, designing, executing complicated experiments, and delivering scientific results in a cross-functional environment. Experience in supervising and managing junior Scientist/Research Associate will be a strong plus.

• Independently plan, design, execute experiments to assess the in-vitro functions of CAR-NK/CAR-T cells
• Develop cell therapy platform and optimize cell-based immunoassays, including ex-vivo antigen-specific T cell isolation and expansion. Multi-color flow cytometry, ELISA, ELISPOT, cytotoxic assays
• Deliver scientific results at internal and external meetings
• Supervise associate scientists for routine laboratory work
• Work collaboratively within internal cross-function teams and external CRO/academic institutes
• Help group leader with general laboratory management
• Serve as the major contributors for pipeline development

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• Ph.D. in cell biology/immunology/oncology
• >2 years’ post-graduate experience in human T-cell biology, immunology, or oncology
• Extensive hands-on experience in CAR-NK/CAR-T cell for cancer immunotherapy
• Familiar with viral vector construction, production, and manipulation (Lentiviral, retroviral and adenoviral vectors )
• Experience in immune cell functional assays (cytotoxicity assay and cytokine release assay)
• Expertise in flow cytometry and ELISA
• Expertise in cell biology and immune cell profiling
• Extensive experience in multi-color flow cytometry
• Experience with immune cells culture (NK cells, T cells, and macrophages cells)
• Track record of scientific publications and accomplishments
• Demonstrated ability in presenting scientific results
• Excellent oral and written communication skills
• A team player who can work efficiently as an individual