Sr. Research Associate, Process Development Job at Moderna Therapeutics

Moderna Therapeutics Norwood, MA 02062

The Role:
Moderna is seeking a highly skilled and motivated process development scientist to join a collaborative and cross-disciplinary team within Technical Development. In this unique role, the applicant will perform experiments that elucidate the fundamental principles of mRNA lipid nanoparticle (mRNA LNP) assembly. The candidate will participate in both independent and collaborative projects within the LNP Process Science team. The candidate will assist in basic nanoparticle characterization activities and will manage more complex characterization efforts in collaboration with our analytical partners. In addition to their primary scope of responsibilities, the incumbent may further participate in scale-up experiments and technology transfer activities to enable clinical supply and late-stage development efforts.

We seek applicants that are proactive, enthusiastic, and show a passion for formulation science and process development. Applicants should enjoy working in a fast-paced and dynamic environment. Applicants should have exceptional time management and communications skills with a strong attention to detail. Previous experience with self-assembly, nanoparticle formulations, nanoparticle characterization tools, process characterization, quality-by-design, and statistical design of experiments (DOE) is preferred. We are seeking candidates with strengths in experimental planning, experiment execution, and scientific communication (i.e., technical writing and scientific presentations).

Here’s What You’ll Do:
Design and execute experiments that elucidate the fundamental drivers of mRNA lipid nanoparticle synthesis and stabilization.

Identify opportunities for process innovation and improvement.

Evaluate and scale existing and novel process modes.

Characterize nanoparticle physicochemical properties by managing collaborative efforts with Analytical partners.

Analyze, interpret, and document experimental data. Communicate outcomes to the Technical Development team and stakeholders.

Collect and share relevant academic literature and establish new collaborations with internal groups.

Here’s What You’ll Bring to the Table:
BS or MS in Chemical Engineering, Chemistry, Pharmaceutical Sciences, Bioengineering or closely related field.

BS with 1-3 years or MS with 0-2 years relevant industry experience.

Ability to thrive in a diverse and fast paced environment.

Excellent written and verbal communication skills.

Preferred: Experience with self-assembly and antisolvent precipitation reactions.

Preferred: Experience with lipid nanoparticle formulations.

Experience with analytics and biophysical characterization of nanoparticles.

Preferred qualifications: hands-on experience with dynamic light scattering, nanoparticle tracking analysis, nanoparticle separation technologies (AF4, SEC), and spectrophotometric techniques.

Preferred: Hands-on experience with pump operations, micro/macromixing technologies, tangential flow filtration (TFF), dialysis purification, and dead-end filtration approaches.

Preferred: Familiarity with nucleic acid, protein, and/or lipid chemistry, and analytical characterization of biomolecules.

Preferred: Working knowledge of statistical design of experiments (DoE), analysis of multivariate data and JMP statistical software .

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:
Highly competitive and inclusive medical, dental and vision coverage options
Flexible Spending Accounts for medical expenses and dependent care expenses
Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
Family care benefits, including subsidized back-up care options and on-demand tutoring
Free premium access to fitness, nutrition, and mindfulness classes
Exclusive preferred pricing on Peloton fitness equipment
Adoption and family-planning benefits
Dedicated care coordination support for our LGBTQ+ community

Generous paid time off, including:
  • Vacation, sick time and holidays
  • Volunteer time to participate within your community
  • D iscretionary year-end shutdown
  • Paid sabbatical after 5 years; every 3 years thereafter
Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
401k match and Financial Planning tools
Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
Complimentary concierge service including home services research, travel booking, and entertainment requests
Free parking or subsidized commuter passes
Location-specific perks and extras!

About Moderna
In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.

Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit www.modernatx.com.

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!

Moderna is proud to be an equal opportunity workplace and is an affirmative action employer.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.

Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We’re focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best.

Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the Talent Acquisition Partner or contact the Accommodations team at leavesandaccommodations@modernatx.com. (EEO/AAP Employer)
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