About Generate Biomedicines

Generate Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. Generate has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate was founded in 2018 by Flagship Pioneering and has received over $420 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Cambridge, Somerville, and Andover with approximately 250+ employees.

The Role:

Generate Biomedicines is seeking to expand the Therapeutic Research team by recruiting a talented Associate Scientist of In Vivo Pharmacology to drive preclinical and IND-enabling studies. This role will work collaboratively across groups to plan, execute and analyze preclinical small animal studies. A wide range of animal models including syngeneic, CDX, PDX and humanized mouse models will be employed. The candidate will be responsible for establishing in-house disease models and managing external CRO run studies. The successful candidate will have a strong attention to detail, high level of organization, strong scientific acumen and a solution-oriented approach. We are searching for an enthusiastic, innovative, and highly motivated individual who is comfortable working in a fast-paced, entrepreneurial environment.

Key responsibilities:

• Establish relevant in vivo models to assess function and pharmacokinetics of therapeutic pipelines in oncology spaces
• Design, perform, and analyze well controlled in vivo experiments to evaluate targets, combination strategies, biomarkers, efficacy and PK/PD relationships.
• Write and present project protocols in compliance with IACUC regulations
• Coordinate and supervise outsourced animal studies at CROs and academic collaborations
• Communicate findings to teams, health agencies, and scientific community as appropriate.

Qualifications:

• Desire and extensive experience working with animals required, preferably in an industrial setting.
• BSc/MSc with 6+ years of experience or PhD in cancer biology or immunology acceptable.
• Experience managing CROs desired.
• Experience with in vivo tumor models required
• Experience with mammalian cell culture required
• Proven track record of performing in vivo procedures in rodents, including preparation and administration of biotherapeutics
• Strong experience with immunological techniques including immunoassays such as high dimensional flow cytometry, ELISA and in vitro and ex vivo primary cell-based assays preferred
• Familiarity with humanized mouse models for immunology and immuno-oncology
• Demonstrated ability to execute experiments, analyze data, and report conclusions
• Excellent cross functional collaboration and interpersonal skills
• Able to thrive in a highly collaborative, fast-paced, team-oriented environment with colleagues from diverse disciplines

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.