Research Associate I, Pre-Clinical Manufacturing Job at Asklepios BioPharmaceutical
Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered.
At AskBio, we’ve built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson’s disease, and congestive heart failure. Our gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library.
We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, and Spain.
Our vision: Pioneering science to create transformative molecular medicines.
Our mission: Lead innovative science and drive clinical outcomes to transform people's lives.
Our principles:
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Advance innovative science by pushing boundaries.
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Bring transformative therapeutics to patients in need.
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Provide an environment for employees to reach their fullest potential.
Our values:
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Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
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Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
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Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
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Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
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Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through.
The Research Associate I, Pre-Clinical Manufacturing reporting to the Team Lead will be responsible for manufacturing of research and GLP grade recombinant Adeno-associated virus (rAAV) vectors as part of AskBio’s Vector Core. The rAAV vectors manufactured will support capsid technology development, intellectual property portfolio and progression of internal and external early-stage gene therapy programs. The successful candidate will have a Bachelor’s or Master’s degree in Chemical Engineering, Chemistry/Biochemistry, or Biology, and have a working knowledge of biologics manufacturing. This position requires execution of small and large-scale manufacturing campaigns with the ability to evaluate and report the results to colleagues. This position will sit onsite in RTP, NC.
Responsibilities
- Responsible for rAAV vector manufacturing for research and GLP grade studies to support rAAV technology improvements and progression of early-stage gene therapy programs.
- Manufacture rAAV vectors by supporting upstream and downstream process activities such as shake flasks, WAVE bioreactors, and stir tank bioreactors, filtration and chromatography technologies.
- Work closely with analytical team to summarize and evaluate manufacturing data and close out batch documentation.
- Support process investigations, improvements, and optimization activities in collaboration with senior research associates and process development scientists.
- Support process development activities, technology transfer and training, internal and external manufacturing and analytical development activities
- Support the preparation of manufacturing reports and make oral presentations to scientists and management.
Required Education and Experience
- BS or MS degree in a biological or engineering discipline required (Biotechnology, Chemistry/Biochemistry, Chemical/Biochemical Engineering, or equivalent).
- 0 - 2 years of relevant experience in lab laboratory research, biologics manufacturing and a desire to continue in a laboratory-focused role. Experience in bioprocess manufacturing, preferably in rAAV and/or recombinant protein/biomolecule bioprocess manufacturing, is a plus.
- Be comfortable with working and learning in a fast-paced laboratory environment.
- Understands basic concepts and principles of rAAV manufacturing operations including cell culture, centrifugation, filtration, and chromatography.
Asklepios BioPharmaceutical, Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job‐related requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at (919) 561-6210 or sending us an email at
careers@askbio.com
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